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Irene Cetin

Born: Legnano (Italy), 4th November, 1958
Married, 2 children.

Education

MD, University of Milano (1983)
Board in Obstetrics and Gynecology, University of Milano (1987)
Fellowship in Perinatal Medicine, University of Colorado (1989)

Posts held

Dr Cetin is Associate Professor of Obstetrics and Gynecology at the Department of Medicine, Surgery and Dentistry, San Paolo Hospital, University of Milano where she is Research Leader on projects concerned with fetal growth and placental transport and function.

Until 1999 she had clinical duties as Head of the High Risk Pregnancy Unit of the Obstetrics and Gynecology Department. Since 2000 she has had clinical duties in the Gynecological Surgery Unit of the Obstetrics and Gynecology Department.

She has a teaching appointment in Prenatal Medicine and in Biotechnology of Human Reproduction at the Medical School of the University of Milano and has been Visiting Associate Professor at the University of Colorado (1993) and at the University of Manchester (1990 and 1996, respectively). She organized the 9th European Placenta Group and the 7th Meeting of the International Federation of Placenta Associations, in Italy, in September 2001. She is a member of the Editorial Boards of the International Scientific Journals Placenta, Biology of the Neonate, and European Journal of Obstetrics & Gynecology and Reproductive Biology.
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Funding

Dr Cetin’s work is funded by the Italian government. Additional external funding obtained in recent years includes funding for international projects on glucose and amino acid metabolism in intrauterine growth restricted (IUGR) pregnancies (1992-1993: NATO Grant for International Collaboration in Research: Amino acid and glucose metabolism in human and animal models; 1992-1996: NICHD Center Grant “Metabolic Regulation of Fetal Growth”. International Collaboration with the Division of Perinatal Medicine, University of Colorado, for Project III “Studies of amino acid and carbohydrate metabolism in intrauterine growth retarded (IUGR) pregnancies”) and on studies of placental amino acid transport using stable isotopes (European Community 1994-1997: BMH1 - CT94 – 1715 Concerted Action: Pathophysiology of impaired placental transfer in intrauterine growth retarded (IUGR) pregnancies: correlation between in vivo and in vitro studies). She has been funded by the European Community for the study of placental oxygen exchange (BMHA-CT98-3621 Concerted Action: Importance of oxygen supply in intrauterine growth restricted (IUGR) pregnancies: correlation between in vivo and in vitro studies). She is coordinating the group in Milano for the project approved by the European Community on “Influence of Dietary Fatty Acids on the Pathophysiology of Intrauterine Foetal Growth and Neonatal Development (PERILIP)” under the Quality of Life and Management of Living Resources, Key Action 1: Food, Nutrition and Health.

Committees and societies

Dr Cetin is a member of the Executive Committee of the International Federation of Placental Associations (IFPA), and is part of its working committee on ethics. She is part of the International Scientific Committee of the European Placental Group (EPG). She is also member of the Perinatal Reearch Society, of the Italian Society of Obstetrics and Gynecology, and of the Italian Society of Perinatal Medicine.

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Selected recent publications

  1. I. CETIN, A.M. MARCONI, A.M. BAGGIANI, M. BUSCAGLIA, G. PARDI, P.V. FENNESSEY, F.C. BATTAGLIA.
    In vivo placental transport of glycine and leucine in human pregnancies.
    Pediatr. Res. 37: 571-575, 1995.
  2. I.CETIN, S.RONZONI, A.M.MARCONI, G.PERUGINO, C.CORBETTA, F.C.BATTAGLIA, G.PARDI
    Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth retarded (IUGR) pregnancies.
    Am.J.Obstet.Gynecol., 174: 1575-1583,1996.
  3. CARPANI G., BOZZETTI P., CETIN I., TEL A., MORONI G.A.
    Sickle cell thalassemia in pregnancy: a case report.
    J. Maternal Fetal Med., 5 :28-30,1996.
  4. G.PARDI, A.M.MARCONI, I.CETIN
    Pathophysiology of intrauterine growth retardation: role of the placenta.
    Acta Paediatr. Suppl. 423: 170-172, 1997.
  5. J.D.GLAZIER, I.CETIN, G.PERUGINO, S.RONZONI, A.M.GREY, D.MAHENDRAN, A.M.MARCONI, G.PARDI, C.P.SIBLEY
    Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction.
    Pediatr. Res. 42: 514-519, 1997.
  6. A.M. MARCONI, C.L. PAOLINI, L. STRAMARE, I. CETIN, P.V. FENNESSEY, G. PARDI.
    The steady state maternal-fetal leucine enrichments in normal and fetal growth restricted pregnancies.
    Pediatr. Res. 46:114-119, 1999.
  7. S. RONZONI, A.M.MARCONI, I. CETIN, C.L. PAOLINI, C. TENG, G. PARDI, F.C. BATTAGLIA.
    Umbilical amino acid uptake at increasing maternal amino acid concentrations: effect of a maternal amino acid infusate.
    Am.J.Obstet.Gynecol. 181: 477-483, 1999.
  8. S.RIGANO, E.FERRAZZI, T.RADAELLI, E.TARICCO, I.CETIN, G.PARDI
    Sonographic measurements of subcutaneous fetal fat in pregnancies complicated by gestational diabetes and in normal pregnancies.
    Croat. Med. J. 41: 240-244, 2000.
  9. I. MARTINELLI, E. TAIOLI, I. CETIN, A.MARINONI, S. GEROSA, M.V. VILLA, M. BOZZO, P.M. MANNUCCI.
    Mutations in coagulation factors in women with unexplained late fetal loss.
    N. Engl. J. Med. 343: 1015-1018, 2000.
  10. I.CETIN, P.S.MORPURGO, T.RADAELLI, E.TARICCO, D.CORTELAZZI, M.BELLOTTI, G.PARDI.
    Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term.
    Pediatr. Res. 48:646-451, 2000.
  11. I.CETIN.
    Amino acid interconversions in the fetal-placental unit: the animal model and human studies in vivo.
    Pediatr. Res. 49: 1-7, 2001.
  12. F.ARCURI, C.RICCI, F.IETTA, M. CINTORINO, S.A.TRIPODI, I.CETIN, E.GARZIA, F.SCHATZ, P. P.KLEMI, R.SANTOPIETRO, L.PAULESU.
    Macrophage migration inhibitory factor in the human endometrium: expression and localization during the menstrual cycle and early pregnancy.
    Biol. Reprod. 64: 1200-1205, 2001.
  13. F.FRANCHI, E.BIGUZZI, I.CETIN, F.FACCHETTI, T.RADAELLI, M.BOZZO, G.PARDI, E.FAIONI.
    Mutations in the thrombomodulin and endothelial protein C receptor genes in women with late fetal loss.
    Brit. J. Haematol. 114: 641-646, 2001.
  14. H.L.GALAN, S.RIGANO, T.RADAELLI, I.CETIN, M.BOZZO, J.CHYU, J.C.HOBBINS, E.FERRAZZI.
    Reduction of subcutaneous mass, but not lean mass, in normal fetuses in Denver, Colorado.
    Am. J. Obstet. Gynecol. 185: 839-844, 2001.
  15. M.MIOZZO, F.R.GRATI, G.BULFAMANTE, F.ROSSELLA, M.CRIBIU’, T.RADAELLI, B.CASSANI, T.PERSICO, I.CETIN, G.PARDI, G.SIMONI.
    Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1 MEST expression.
    Placenta 22: 813-821, 2001.
  16. I.CETIN, T.RADAELLI, E.TARICCO, N.GIOVANNINI, G.ALVINO, G.PARDI.
    The endocrine and metabolic profile of the growth retarded fetus.
    J. Pediatr. Endocr. Met. 14 (Suppl 6), 1497-1505, 2001.
  17. T.RADAELLI, I.CETIN, P.T-Y AYUK, J.GLAZIER, G.PARDI, C.SIBLEY.
    Cationic amino acid transporter activity in the syncytiotrophoblast microvillous plasma membrane and oxygenation of the uteroplacental unit.
    Trophoblast Research, 23, S69-S64, 2002.
  18. C.P.SIBLEY, G.PARDI, I.CETIN, T.TODROS, E.PICCOLI, P.KAUFMANN, B.HUPPERTZ, G.BULFAMANTE, F.M.CRIBIU’, P.AYUK, J.GLAZIER, T.RADAELLI.
    Workshop Report: Pathogenesis of Intrauterine Growth Restriction (IUGR) – Conclusions Derived from a European Union Biomed. 2 Concerted Action Project `Importance of Oxygen Supply in Intrauterine Growth Restricted Pregnancies’.
    Trophoblast Research, 23, S75-S79, 2002.
  19. G.PARDI, A.M.MARCONI, I.CETIN.
    Placental-fetal Interrelationship in IUGR Fetuses-A Review.
    Trophoblast Research, 23, S136-S141, 2002.
  20. I.CETIN, E.BIGUZZI.
    Foetal growth restriction in children with prothrombotic risk factors – a rebuttal.
    Thrombosis and Haemostasis, 2002, 87: 926.
  21. I.CETIN, N.GIOVANNINI, G.ALVINO, C.AGOSTONI, E.RIVA, M.GIOVANNINI, G.PARDI.
    Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships.
    Pediatr. Res. 52, 750-755, 2002.
  22. T. RADAELLI, I.CETIN, P.ZAMPERINI, E.FERRAZZI, G.PARDI.
    Intrauterine growth of normal thyroid.
    Gynecol. Endocrinol. 16: 1-4, 2002.
  23. I.MARTINELLI, E.TAIOLI, I.CETIN, P.M.MANNUCCI.
    Recurrent late fetal death in women with and without trombophilia.
    Thrombosis and Haemostasis 87: 358-359, 2002 (letter).

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Emanuela Taricco

Born: Milano (Italy), 17th June, 1974

Education and employment

MD, University of Milano (1999)
Board in Obstetrics and Gynecology, University of Milano

Funding

Dr Taricco is part of the group in Milano for the project approved by the European Community on “Influence of Dietary Fatty Acids on the Pathophysiology of Intrauterine Foetal Growth and Neonatal Development (PERILIP)” under the Quality of Life and Management of Living Resources, Key Action 1: Food, Nutrition and Health.

Research interests

  1. In vivo experimental study of placental amino acid transport and umbilical amino acid uptakes in pregnancies associated with intrauterine growth restriction and in pregnancies with gestational diabetes.
  2. Ultrasound evaluation of foetal fat and lean mass during pregnancy: comparison of traditional parameters of foetal growth with new parameters of fat and lean mass in normal cases and in pregnancies associated with gestational diabetes.
  3. Randomized study of treatment in gestational diabetes: traditional approach versus a new approach considering not only maternal glycaemic control but also the indirect evaluation of foetal insulinization by studying the pattern of foetal growth.
  4. Evaluation of the early maternal adaptation to pregnancy, particularly by studying changes in maternal cardiovascular function and changes in maternal metabolism of amino acids and fatty acids.

Selected recent publications

  1. S.RIGANO, E.FERRAZZI, T.RADAELLI, E.TARICCO, I.CETIN, G.PARDI
    Sonographic measurements of subcutaneous fetal fat in pregnancies complicated by gestational diabetes and in normal pregnancies.
    Croat. Med. J. 41: 240-244, 2000.
  2. I.CETIN, P.S.MORPURGO, T.RADAELLI, E.TARICCO, D.CORTELAZZI, M.BELLOTTI, G.PARDI.
    Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term.
    Pediatr. Res. 48:646-451, 2000.
  3. I.CETIN, T.RADAELLI, E.TARICCO, N.GIOVANNINI, G.ALVINO, G.PARDI.
    The endocrine and metabolic profile of the growth retarded fetus.
    J. Pediatr. Endocr. Met. 14 (Suppl 6), 1497-1505, 2001.

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Gioia Alvino

Born: Avellino (Italy), 2nd June, 1975

Education and employment

MD, University of Milano (2000)
Resident in Obstetrics and Gynecology, University of Milano.

Research interests

  1. Evaluation of fatty acid profile in mothers and fetuses during pregnancy: comparison between normal pregnancies and IUGR pregnancies at fetal blood sampling (FBS) performed for prenatal diagnosis.

  2. Evaluation of dietary intake: maternal dietary habits studied by food-frequency questionnaire in the first and third trimesters and at delivery.

  3. Influence of dietary fatty acids on newborn outcome: importance of a fatty acid supplementation on pregnancy length and fetal weight.

  4. Evaluation of fatty acid profile in normal, IUGR and diabetic pregnancies at delivery: comparison of fetal and maternal blood composition with the fatty acid composition of maternal fat tissue.

Selected recent publications

  1. I.CETIN, T.RADAELLI, E.TARICCO, N.GIOVANNINI, G.ALVINO, G.PARDI.
    The endocrine and metabolic profile of the growth retarded fetus.
    J. Pediatr. Endocr. Met. 14 (Suppl 6), 1497-1505, 2001.
  2. I.CETIN, N.GIOVANNINI, G.ALVINO, C.AGOSTONI, E.RIVA, M.GIOVANNINI, G.PARDI.
    Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships.
    Pediatr. Res. accepted 2002.

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Silvia Tabano

Born: Tradate (VA-Italy), 3rd August 1975.

Education and employment

July 2001 Masters degree in Biological Sciences with molecular biology specialisation
Nov.2000-July 2001

Student (preparating thesis) in the Cytogenetics and Medical Genetics laboratory at the Varese Hospital
Title of project: Cytogenetic detection and characterization of structural chromosomal abnormalities resulting in phenotypic anomalies: a resource for the genotype-phenotype correlations.
Techniques used: cell cultures, cariotype analysis, fluorescent in situ hydridization
Sept.2001-July 2002

Researcher at the Istituto Nazionale Tumori (Milano) in the Molecular Diagnostic Laboratory (Pathologic anatomy division) .
Title of project: Individuation and characterization of genetic and epigenetic alterations of the three tumor suppressor genes p15INK4b, p14ARF and p16INK4a, located at the locus 9p21, involved in molecular pathogenesis of malignant peripheral nerve sheat tumors and intestinal type adenocarcinomas (ITACs).
Techniques used: DNA extraction, purification and modification, RNA extraction, PCR, detection of DNA fragments in agarose and polyacrylamide gels.
Aug. 2002-present

Researcher in the Obstetrics and Gynecology Department, University of Milano.
Title of project: Influence of Dietary Fatty Acids on the Pathophysiology of Intrauterine Foetal Growth and Neonatal Development (PERILIP).
Collaborating with the Human Genetics laboratory of the University of Milano .
Project of study: Search of uniparental disomy as cause of  IUGR conceptuses.
Techniques used: DNA, RNA extraction, PCR, DGE, DNA sequencing.
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Veronica Cozzi

Born: Milano (Italy), 9th May 1976

Education

MD, University of Milano (2001).

Funding

Dr Cozzi is currently the recipient of funds from the Italian Government for her Board in Obstetrics and Gynecology. She is part of the research group in Milano for the project approved by the European Community on “Influence of Dietary Fatty Acids on the Pathophysiology of Intrauterine Foetal Growth and Neonatal Development (PERILIP)” under the Quality of Life and Management of Living Resources, Key Action 1: Food, Nutrition and Health.

Research Interests

  1. Evaluation of endometrial receptivity and the specific role of cytokines as immunoregulatory agents at the time of embryo implantation: expression of endometrial prolactin and prolactin receptor in autocrine/paracrine interactions at the maternal-fetal interface during implantation and placentation in women selected for unexplained infertility or recurrent early miscarriages.

  2. Evaluation of follicle-stimulating hormone receptor (FSH-R) in women developing ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) cycles: investigation of the potential role of FSH-R isoforms in the pathophysiology of this syndrome.

  3. Evaluation of placental and maternal hormones involved in the regulation of insulin resistance and fat metabolism in pregnancies associated with intrauterine growth restriction (IUGR).

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